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Details of MBC Grants Dataset from 2000–2013
Each record in the MBC Grants dataset was analyzed and assigned to 1 or more steps of
metastasis. As shown in Figure 6, 815 grants (36%) were investigating aspects of invasion,
670 (29%) were looking at metastatic colonization, 177 (8%) were studying intravasation and
circulation, 47 (2%) focused on immune surveillance/escape, 26 (1%) were investigating arrest
and extravasation, and 13 (1%) were studying metabolic deregulation. A total of 295 awards
(13%) could not be categorized into a metastatic stage and were classified as “other”; and
238 (10%) were classified into more than 1 metastatic stage. These percentages did not vary
substantially from year to year from 2000 through 2013.

Figure 6: Grants Categorized by Steps in Metastatic Process

40%
invasion (815)

metastatic
colonization (670)
30%

20%
not relevant
other/not specified (295)
multiple
intravasation (238)
10% & circulation (177) metabolic
deregulation
5% (13)
2.5%
0%
arrest & immune
extravasation (26) surveillance/escape (47)

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