Page 38 - MBCA_FULL REPORT_FINAL_FOR_WEB

Figure 3: 162 MBC Clinical Trials Assigned to the Hallmarks of Cancer Framework

SUSTAINING PROLIFERATIVE SIGNALING EVADING GROWTH SUPPRESSORS AVOIDING IMMUNE DESTRUCTION ENABLING REPLICATIVE IMMORTALITY TUMOR-PROMOTING INFLAMMATION ACTIVATING INVASION & METASTASIS INDUCING ANGIOGENESIS GENOME INSTABILITY AND MUTATION RESISTING CELL DEATH DEREGULATIN

95 9

0 27

Active MBC

1 Clinical Trials 0
Categorized by the
Hallmarks of Cancer:
The Next Generation
25 0

4 1

GENOME
INSTABILITY AND
MUTATION
PARP inhibitors ACTIVE CLINICAL TRIAL DETAILS
HDAC inhibitors* Note: 37 additional trials not targeted or could not be assigned to a hallmark
Minor groove of DNA
inhibitor (PM01183) INDUCING ACTIVATING TUMOR- ENABLING
ANGIOGENESIS INVASION AND PROMOTING REPLICATIVE IMMORTALITY
RESISTING CELL VEGF inhibitors METASTASIS INFLAMMATION GRN163L trial halted in MBC in 2013
DEATH TGF-b inhibitor Inflammation remains Other telomerase inhibitors in trials
IAP (inhibit apoptosis (fresolimumab) of key interest in BC for hematologic cancers
proteins) (LCL161)
SUSTAINING PROLIFERATIVE EVADING GROWTH SUPPRESSORS AVOIDING IMMUNE
DEREGULATING SIGNALING CDK inhibitors Agents: DESTRUCTION
CELLULAR PI3/Akt/mTOR Hormone-mediated Palbociclib 18 vaccine
ENERGETICS JAK PTEN LEE011 7 immunomodulators
DIG-HIF1 being studied Notch RAF/MEK/ERK/ALK Y2835219
in early BC. Phase II ERB receptors Other
*does not relate to "Genome Instability and Mutation" hallmark but instead is a modulator of transcription that is not easily t into any one of the hallmark categories.
Abbreviations: BC = breast cancer; BH3 = pro-apoptotic member of the Bcl-2 protein family; anti-CTLA4 mAb = anti–cytotoxic T-lymphocyte
38 associated protein 4 monoclonal antibody; CDK = cyclin-dependent kinase; DNA = deoxyribonucleic acid; EFGR, ERB = another term
for ErbB, the epidermal growth factor receptor protein family; HDAC = histone deacetylase; HGF/c-Met = hepatocyte growth factor/MET
proto-oncogene, receptor tyrosine kinase; JAK = Janus kinase family; MBC = metastatic breast cancer; Notch = family of proteins involved
in intracellular signaling; PARP = poly-ADP ribose polymerase; PTEN = phosphatase and tensin homolog; RAF/MEK/ERK/ALK = a key cellular
signaling pathway; TGF-b = transforming growth factor beta; VEGF = vascular endothelial growth factor.