Page 125 - MBCA_FULL REPORT_FINAL_FOR_WEB

Basic research awards Translational research awards Clinical research awards
lysine oxidase (LOX) 0.4% tumor associated macrophages 0.4% receptor tyrosine kinase 0%
(TAMs)
PAR 0.4% TWIST transcription factos 0.4% EGF pathway 0%
SLUG/SNAIL 0.3% PGE2 receptors 0.3% nuclear protooncoproteins 0%
Actin 0.3% HLA 0.3% FAK 0%
Abl Kinases 0.3% S100 family of Ca2+-binding pro- 0.3% tumor suppressor genes 0%
teins
Basic research awards Translational research awards Clinical research awards p53 pathway 0.3% TF Signaling 0.3% Interleukins 0%
Pathway (Group) Total Molecular Target (Group) Total Molecular Target (Group) Total
Other 22.0% Other 23.4% Other 24% BRCA 0.3% Src + family 0.3% HOX family transcription factors 0%
metastasis suppressor genes
0.3%
HDAC
0.3%
0%
transcription factor
Multiple 12.5% 0_No specific target 16.4% 0_No specific target 17%
Bone/osteolysis pathways 6.7% Multiple 7.4% Multiple 11% HOX homeobox factors 0.3% p53 pathway 0.3% immunophilin proteins 0%
PTHrP
0.3%
immunophilin proteins
0.3%
0%
AKT
Pathway not specified 4.9% Integrins, Cadherins etc. 3.9% Erb/Her 6%
Angiogenic pathways 4.6% Erb/Her 3.1% hormone receptors 5% Phosphoinsitide signaling 0.3% anthrax toxin receptor 2 (CMG2) 0.3% telomeres 0%
0.3%
COX
0.3%
Plasminogen signalling
0%
SDF-1
Integrins, Cadherins etc. 3.4% cytokines and chemokines 3.0% VEGF pathway family 3%
TGF 3.3% Bone/osteolysis pathways 2.7% (blank) 3% Fibroblast activation pro- 0.3% Retinoids 0.3% G-protein coupled receptors 0%
tein (FAP)
cytokines and chemokines 2.9% Stem cells 2.5% IGF signalling 3% SDF-1 0.3% telomeres 0.3% Ezrin 0%
Stem cells 1.8% TGF 2.1% Bone/osteolysis pathways 3% adhesion molecules 0.2% PI3 kinase 0.2% HDAC 0%
Hypoxia factors 1.5% matrix metalloproteinases 2.0% HGF/MET 2% IBC 0.2% Vitamin D pathway 0.2% tumor associated macrophages 0%
matrix metalloproteinases 1.5% VEGF pathway family 1.8% urokinase (uPA-R) pathway 2% (TAMs)
Rho family GTPases 1.4% (blank) 1.8% angiogenesis factor 2% sympathetic nervous sys- 0.2% Hedgehog 0.2% SIX family genes 0%
VEGF pathway family 1.4% angiogenesis factor 1.7% Immune system (general) 2% tem (SNS) signalling
Erb/Her 1.4% Circulating tumour cells (CTC) 1.4% thymidylate synthase 2% tumor necrosis family (TNF) 0.2% bcl-2 family 0.2% Hypoxia factors 0%
Immune system (general) 1.3% Hypoxia factors 1.4% p53 pathway 2% superfamily
Src + family 1.0% NF Kappa B pathway 1.2% Integrins, Cadherins etc. 1% Oncostatin M 0.2% tumor homing peptides 0.2% G protein coupled receptors 0%
NF Kappa B pathway 1.0% hormone receptors 1.0% Src + family 1% PTEN 0.2% src kinase substrate 0.2% Vitamin D pathway 0%
hormone receptors 1.0% Interleukins 0.9% cytokines and chemokines 1% p21 activated kinase (PAK) 0.2% Ras pathway 0.2% lysophospholipid family 0%
microRNAs (miRNAs) 1.0% urokinase (uPA-R) pathway 0.9% COX 1% Crk family 0.2% autocrine motility factor (AMF) 0.2% Cell surface glycoproteins 0%
Six family genes 0.8% Immune system (general) 0.9% Stem cells 1% telomeres 0.2% STAT 0.2% scaffolding adapters 0%
tumor microenvironment 0.2% endoglycosidases 0.2% HLA 0%
FAK 0.8% EGF pathway 0.8% HSP 1%
Twist 0.8% cysteine proteases 0.8% TGF 1% p38 pathways 0.2% Notch pathway 0.2% claudins 0%
brain 0.2% disintegrin family 0.2% tumor homing peptides 0%
STAT 0.7% tumor necrosis family (TNF) 0.8% Ras pathway 1%
superfamily TF Signaling 0.2% SDF-1 0.2% Plasminogen signalling 0%
receptor tyrosine kinase 0.6% Fibroblast activation protein (FAP) 0.7% PI3 kinase 1% ezrin 0.2% sialylation 0.2% Retinoids 0%
Cell surface glycoproteins 0.6% IGF signalling 0.7% disintegrin family 1% map kinases 0.2% tubulin binding agent 0.2% autocrine motility factor (AMF) 0%
cytoskeleton 0.6% COX 0.7% breast tumor suppressors 1% transcription factor 0.2% metastasis suppressor genes 0.2% Cystatin M 0%
Protein kinases 0.5% Ephrins 0.7% Circulating tumour cells (CTC) 1% Interleukins 0.2% receptor tyrosine kinase 0.2% Ubiquitin ligases 0%
Ras pathway 0.5% HSP 0.6% MUC1 0% ALDH 0.2% HDAC 0.2% NF Kappa B pathway 0%
HGF/MET 0.5% NK cells 0.6% matrix metalloproteinases 0% serine protease 0.2% Thrombospondins 0.2% SLUG/SNAIL 0%
Collagen 0.5% p38 pathway 0.5% minor fatty acids 0% IGF signalling 0.2% G-protein coupled receptors 0.2% STAT 0%
MUC1 0.5% Galectins 0.5% ID-2/ID-1 0% Plasminogen signalling 0.2% miRNAs 0.2% p21-activated kinase (Pak1) 0%
stress pathways 0.5% Rho family GTPases 0.5% tumor necrosis family (TNF) super- 0% HSP 0.2% protein tyrosine kinase 0.2% TF Signaling 0%
family Leptin 0.2% lysine oxidase (LOX) 0.1% BCRP 0%
FGF signalling 0.5% Cell surface glycoproteins 0.5% Rho family GTPases 0% Hedgehog 0.2% indoles 0.1% metastasis associated (MTA) 0%
brain metastases 0.5% ID-2/ID-1 0.4% FGF signalling 0% Notch pathway 0.2% breast tumor suppressors 0.1% NK cells 0%
Ephrins 0.4% MUC1 0.4% Fibroblast activation protein (FAP) 0% liver 0.2% Protein-tyrosine kinases (PTKs) 0.1% miRNAs 0%
Wnt signalling 0.4% AKT PKB signalling 0.4% prolactin (PRL) 0% SATB1 0.2% Sphingosines 0.1% anthrax toxin receptor 2 (CMG2) 0%
insulin receptor substrate 0.4% FAK 0.4% transcription factor 0% Neuropilin 0.2% metastasis associated (MTA) 0.1% sialylation 0%
(IRS) ADAM 0.2% lysophospholipid family 0.1% endoglycosidases 0%
metastasis suppressor 0.4% PTHrP 0.4% proteases 0% tumor suppressor genes 0.2% proteases 0.1% Galectins 0%
genes