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Appendix 4: Examples of How Grants in the MBC Grants Dataset Were Further Categorized
into the Metastasis Stage

Molecular pathways and targets (CY 2000 - 2013)
Includes any awards active over this thirteen year period
Awards are categorized into Basic, Translational or Clinical, based on their CSO profile
Where possible, pathways/targets have been grouped into categories

Basic research awards Translational research awards Clinical research awards
Pathway (Group) Total Molecular Target (Group) Total Molecular Target (Group) Total
Other 22.0% Other 23.4% Other 24%
Multiple 12.5% 0_No specific target 16.4% 0_No specific target 17%
Bone/osteolysis pathways 6.7% Multiple 7.4% Multiple 11%
Pathway not specified 4.9% Integrins, Cadherins etc. 3.9% Erb/Her 6%
Angiogenic pathways 4.6% Erb/Her 3.1% hormone receptors 5%
Integrins, Cadherins etc. 3.4% cytokines and chemokines 3.0% VEGF pathway family 3%
TGF 3.3% Bone/osteolysis pathways 2.7% (blank) 3%
cytokines and chemokines 2.9% Stem cells 2.5% IGF signalling 3%
Stem cells 1.8% TGF 2.1% Bone/osteolysis pathways 3%
Hypoxia factors 1.5% matrix metalloproteinases 2.0% HGF/MET 2%
matrix metalloproteinases 1.5% VEGF pathway family 1.8% urokinase (uPA-R) pathway 2%
Rho family GTPases 1.4% (blank) 1.8% angiogenesis factor 2%
VEGF pathway family 1.4% angiogenesis factor 1.7% Immune system (general) 2%
Erb/Her 1.4% Circulating tumour cells (CTC) 1.4% thymidylate synthase 2%
Immune system (general) 1.3% Hypoxia factors 1.4% p53 pathway 2%
Src + family 1.0% NF Kappa B pathway 1.2% Integrins, Cadherins etc. 1%
NF Kappa B pathway 1.0% hormone receptors 1.0% Src + family 1%
hormone receptors 1.0% Interleukins 0.9% cytokines and chemokines 1%
microRNAs (miRNAs) 1.0% urokinase (uPA-R) pathway 0.9% COX 1%
Six family genes 0.8% Immune system (general) 0.9% Stem cells 1%
FAK 0.8% EGF pathway 0.8% HSP 1%
Twist 0.8% cysteine proteases 0.8% TGF 1%
STAT 0.7% tumor necrosis family (TNF) 0.8% Ras pathway 1%
superfamily
receptor tyrosine kinase 0.6% Fibroblast activation protein (FAP) 0.7% PI3 kinase 1%
Cell surface glycoproteins 0.6% IGF signalling 0.7% disintegrin family 1%
cytoskeleton 0.6% COX 0.7% breast tumor suppressors 1%
Protein kinases 0.5% Ephrins 0.7% Circulating tumour cells (CTC) 1%
Ras pathway 0.5% HSP 0.6% MUC1 0%
HGF/MET 0.5% NK cells 0.6% matrix metalloproteinases 0%
Collagen 0.5% p38 pathway 0.5% minor fatty acids 0%
MUC1 0.5% Galectins 0.5% ID-2/ID-1 0%
stress pathways 0.5% Rho family GTPases 0.5% tumor necrosis family (TNF) super- 0%
family
FGF signalling 0.5% Cell surface glycoproteins 0.5% Rho family GTPases 0%
brain metastases 0.5% ID-2/ID-1 0.4% FGF signalling 0%
Ephrins 0.4% MUC1 0.4% Fibroblast activation protein (FAP) 0%
Wnt signalling 0.4% AKT PKB signalling 0.4% prolactin (PRL) 0%
insulin receptor substrate 0.4% FAK 0.4% transcription factor 0%
(IRS)
metastasis suppressor 0.4% PTHrP 0.4% proteases 0%
genes