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Table 8. Changes in Median Survival of MBC Over Time, According to Study

Time Median Survival
Authors, year Population Database
Frame Change over Time
• Increase from 20
months to 27 months
among non-Hispanic
Dawood et al. >15,000 de novo MBC NCI SEER 1988– white women
2008 [103] Registries, US 2003
• No change (from 17
months) among black
women
British Columbia
Chia et al. 2007 1991– Increase from 14 months
[104] 2150 MBC patients Cancer Agency, 2001 to 22 months
Canada
MD Anderson
Giordano et al. 834 patients with Cancer Center, 1974– Increase from 15 months
2004 [105] recurrent MBC* 2000 to 58 months
US
Ruiterkamp et al. 8000 patients with de Netherlands 1995– Increase from 17 months
2011 [106] novo MBC Cancer Registry 2008 to 23 months
South-East
Ernst et al. 2007 1089 patients with de novo 1975– Increase from 18 months
[107] MBC Netherlands 2002 to 21 months
Registry
Increase from 23 to 29
months overall

• Increase from 28
Andre et al. 2004 724 patients with de novo 3 French cancer 1987–
[108] MBC centers 2000 months to 45 months
among patients with
ER+ MBC

• No change among
those with ER− MBC
Abbreviations: ER = estrogen receptor, MBC = metastatic breast cancer, NCI = National Cancer Institute,
SEER = Surveillance, Epidemiology, and End Results program, US = United States.
* Sample included patients with locally advanced relapse.

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