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Study Drug(s) Target Biomarkers/ Combination Sponsor
Subtype
BMN 673 PARP BRCA+ National Cancer Institute
AZD2281 (olaparib) PARP BRCA+ Carboplatin National Cancer Institute
AZD2281 (olaparib) PARP All With/without carbo- National Cancer Institute
platin
Rucaparib PARP BRCA+ Clovis Oncology
Niraparib PARP HER2- TESARO
HDAC Inhibitors Vorinostat HDAC
Unknown as of 8/1 Vorinostat HDAC All Capecitabine Yale Cancer Center/Merck
Vorinostat HDAC All Paclitaxel, carboplatin National Cancer Institute
Etinostat HDAC HER2+ Lapatinib National Cancer Institute/MD
Anderson Cancer Center
Romidepsin HDAC Protein-bound pacli- Thomas Jefferson University/
taxel Celgene
Romidepsin HDAC All National Cancer Institute
Entinostat HDAC Hormone+_HER2- Exemestane National Cancer Institute
Entinostat HDAC Hormone+_HER2- Exemestane National Cancer Institute
Other PM01183 Minor groove BRCA+ PharmaMar
of DNA
Subtotal
7. Tumor Promoting NOT IN TRIALS FOR
Inflammation MBC
8. Deregulating Cel- NOT IN TRIALS FOR
lular Energetics MBC
9. Activating Invasion
and Metastasis
Fresolimumab (GC1008) TGF-Beta All Radiotherapy New York University
10. Avoiding Immune
Destruction
Vaccines AntiHER2/antiCD3-acti- HER2, CD3 HER2- Cyclophophamide
vated T Cells
AdHER2/neu dendritic ERB2 HER2+ National Cancer Institute
cell vaccine
HER2 peptide-based ERB2 HER2+ University of Washington
Vaccine
Dendritic cell vaccine Tumor antigen All Southern Cancer Center
with oncofetal antigen/ OFA/iLRP
iLRP
Designer T cells CEA CEA+ Roger Williams Medical Center
HER2neu DNA Vaccine ERB2 HER2+ Sloan Kettering
HER2 ICD Peptide Vac- ERB2 HER2+ Trastuzumab/ University of Washington
cine polysaccharide-K
Active, not recruiting Mammaglobin-A DNA Mammaglobin- All Washington University,
Vaccine A St. Louis
ONT-10 MUC1 All Oncothyreon
cMet RNA chimeric Tumor anti- All Abramson Cancer Center,
antigen receptor (CAR) gens University of Pennsylvania
T cells
FANG vaccine (bi- Tumor anti- All Gradalis, Inc.
shRNAfurin and GMCSF gens
autologous tumor cells)
OPT-822/OPT-821 Globo H All cyclophosphamide OBI Pharma, Inc.
hTERT/survivin multi- hTERT All basiliximab, GM-CSF Abramson Cancer Center,
peptide vaccine and Prevnar University of Pennsylvania